After five weeks of war, the US and Iran on April 8 agreed to a two-week ceasefire brokered by Pakistan. Its basic details, however, and to what extent it will be implemented, are surrounded by uncertainty. A main sticking point is the question of whether Lebanon was included in the deal. Iranian and Pakistani officials are insisting it was, but the US and Israel say that it wasn't. Meanwhile, Israel has continued to carry out devastating attacks on Beirut and other parts of Lebanon.

UN Human Rights Chief Volker Türk warned April 1 that repression of freedom of expression across the Middle East has deepened significantly since the US-Israeli attacks on Iran commenced at the end of February.

The World Food Programme (WFP) warned March 17 that the escalating hostilities in the Middle East could lead to record levels of food insecurity, and the largest disruption in the global economy and humanitarian efforts since the COVID-19 pandemic.

United Nations officials said on March 10 that US and Israeli airstrikes on fuel depots in Tehran have released large amounts of toxic pollutants, producing acidic "black rain" across parts of the capital.

The United Nations on March 3 urgently called for civilian protection amid growing violence and instability in the Middle East—and particularly in regard to the ongoing US and Israeli military operations against Iran. The UN urged a thorough investigation into a deadly strike on a girls' school in Iran, and requested the disclosure of all relevant information.

On Feb. 28, the United States and Israel launched coordinated military strikes on Iran, hitting targets in Tehran, Isfahan, Qom and other cities across 24 provinces. Iran's Red Crescent reported at least 201 people killed and 700 injured. US President Donald Trump announced "major combat operations" and openly urged regime change. Iran retaliated by launching missiles at Israel and US military installations across the Gulf States.

Violence has once again broken out between Afghanistan and Pakistan, with Islamabad declaring "open war" on Kabul. Late on Feb. 26, Afghan forces fired on military bases across the border in Pakistan, reportedly using drones. Pakistan retaliated early overnight on Feb. 27, bombing what it said were military and infrastructure targets in Kabul and several border provinces. Afghanistan's Islamic Emirate government said its attacks were a response to Pakistani airstrikes on Feb. 21 and 22 that reportedly killed at least 13 civilians in Nangarhar province. Pakistan accuses the Taliban-led government of harboring fighters from the Tehrik-e Taliban Pakistan (TTP)—accused of being behind recent attacks in Islamabad and Peshawar. Afghan Minister of Interior Sirajuddin Haqqani said the "doors for dialogue" remain open but insisted that if Afghanistan continues to be attacked, it will respond. Iran, a mutual neighbor, has offered to mediate between the two sides. Türkiye and Qatar helped to forge a fragile ceasefire after a previous flare-up in October.

A group of 21 Arab, African and Islamic nations on Dec. 27 issued a joint statement formally rejecting Israel's recognition of Somaliland as an independent state. The statement asserted that recognizing Somaliland as a nation independent of Somalia constitutes a grave violation of international law, emphasizing the "serious repercussions of such [an] unprecedented measure on peace and security in the Horn of Africa, the Red Sea, and its serious effects on international peace and security as a whole."