Two Palestinian water delivery truck drivers were killed by Israeli fire in the Gaza Strip on April 17, prompting aid groups to halt activities in the area. The UN Children's Fund (UNICEF) warned that the attack threatens vital humanitarian operations supplying clean water to hundreds of thousands of people.

South Sudan's military and opposition forces have blocked humanitarian access and unjustifiably ordered civilians to evacuate populated areas, Human Rights Watch (HRW) said April 12. The country's military has issued multiple evacuation orders since late 2025, at least three of which have been "sweeping in nature." Over the same period, opposition forces occupying areas of the country have also issued at least three such orders. As a result, hundreds of thousands of civilians have been forced to flee their homes.

Panama Ports Company SA (PPC), a subsidiary of the Hong Kong-based conglomerate CK Hutchison, commenced arbitration proceedings against Danish shipping firm Maersk A/S on April 7 over the planned takeover by Maersk of PPC's port terminals in Panama.

UN Special Rapporteurs on April 9 condemned an ongoing strategy by Russian authorities to silence dissent, human rights advocacy, and anti-war expression. They warned that this represents a "systematic dismantling" of civil society under the guise of protecting national security and public safety.

The United Nations called upon the international community April 6 to provide immediate support for Cuba amid a worsening humanitarian crisis caused by a US-imposed oil blockade and compounded by the effects of Hurricane Melissa, which struck the country in October 2025.

The UN Committee on Enforced Disappearances (CED) requested April 2 that the United Nations secretary-general refer the crisis of enforced disappearances in Mexico to the General Assembly for consideration of response measures.

UN Human Rights Chief Volker Türk warned April 1 that repression of freedom of expression across the Middle East has deepened significantly since the US-Israeli attacks on Iran commenced at the end of February.

Human Rights Watch (HRW) released a statement March 31 condemning the "unlawful use of lethal force outside any context of armed conflict" by the US military over the past recent months. The statement said that the deadly US strikes on vessels thought to be carrying illegal drugs in the Caribbean and eastern Pacific amount to "extrajudicial executions."