The UN special envoy for Syria, Geir Pedersen, warned April 25 of grave consequences for the country's future without genuine political inclusion and urgent economic support for a successful political transition. During a briefing to the Security Council, Pedersen noted the legacies of misrule, conflict and exclusion in Syria, stating:

This means that the situation is inherently still extremely fragile. The vital ingredients to address this fragility are clear: we need genuine political inclusion so that all Syrians can participate meaningfully in shaping their country's political future, along with countering extremism and terrorism; and real support from the international community to give this transition a chance to succeed against great odds.

Detained Syrians held in harsh conditions in Lebanon are demanding their release, asserting that the fall of the Bashar Assad dictatorship invalidates the terrorism-related charges against them, which were originally made due to their support for the opposition or affiliation with the rebel Free Syrian Army. Since the revolution began in 2011, hundreds of Syrian refugees have been detained in Lebanon, sometimes in relation to their supposed membership in armed groups, but often arbitrarily. 

Israel's ongoing military actions in Syria undermine the Arab country's political transition, and the opportunity for Syria and Israel to form a new security agreement, UN Assistant Secretary General for Political and Peacebuilding Affairs Khaled Khiari said before the Security Council on April 10.

UN experts on April 7 called for an end to the arbitrary, indefinite detention of tens of thousands of people in camps in northeast Syria. The detained individuals are those whom the local Syrian Democratic Forces (SDF) have accused of adherence to the extremist group Islamic State in Iraq & the Levant (ISIL), with over 52,000 people currently held without any due process, 60% of whom are children.

The United Nations Human Rights Council on April 4 passed a resolution demanding accountability for violations and abuses by Syria's ousted Bashar Assad regime through "transitional justice," and declaring support for "the commitments of the interim authorities"  to an "orderly and inclusive transition" and establishment of a timeline for free elections. Assad al-Shaibani, foreign minister of the newly re-founded Syrian Arab Republic, welcomed the resolution, viewing it as an acknowledgement of the government's "local and international efforts to protect human rights."

Some of the world's poorest countries, including nations grappling with protracted humanitarian crises, are among those most affected by US President Donald Trump's new trade tariffs regime, which has compounded pre-existing economic strains and debt woes. Asian markets will be particularly hard hit, including imports to the US from Myanmar to be charged at 45%, and Bangladesh at 37%. Big charges were also imposed on fragile economies in the Middle East and North Africa, with Syria at 41%, Libya at 31%, and Iraq at 39%. But among the worst effects will likely be felt in Africa, where Trump's decision has created an "inexplicably cruel situation," according to the Center for Global Development (CGD). "It is hard to fathom that the administration set out to destabilize poor African countries and unclear what they hope to gain," wrote CGD researchers. The tariffs have effectively tanked the African Growth & Opportunity Act (AGOA), which allowed duty-free imports to the US for 32 countries and was credited with helping economic growth. Lesotho and Madagascar could be among the Trump tariffs' biggest losers, CGD predicted. Amid existential financial worries in the international aid sector—triggered by Trump's closure of USAID—economists have also raised the possibility of a global trade war, with far-reaching ramifications for inflation and the cost of living worldwide.

The Israeli military on April 2 carried out air-strikes on several sites in Syria—including Tiyas airbase, also known as T4, and Palmyra airbase, both in Homs province. The interim government in Damascus called the strikes "a blatant violation of international law and Syrian sovereignty." Israeli Defense Minister Israel Katz responded in a statement addressed to President Ahmed al-Sharaa: "If you allow forces hostile to Israel to enter Syria and endanger Israeli security interests—you will pay a very heavy price." This was a barely veiled reference to Turkey. Local media reports indicate that Turkish forces are preparing to deploy to the T4 and Palmyra bases. Ankara reportedly plans to install Hisar-O and Hisar-U air defense systems and potentially the long-range SIPER system at these locations. The deployment of a Russian-made S-400 system is also under consideration, pending Moscow's approval. 

Syria's interim president Ahmed al-Sharaa and Syrian Democratic Forces (SDF) chief Mazloum Abdi signed an agreement on March 10 to integrate the Kurdish-led SDF into Syria's state institutions. A statement by the Syrian Presidency said a pact was reached to "integrate all civil and military institutions in northeast Syria [Rojava] under the administration of the Syrian state, including border crossings, the [Qamishli] Airport, and oil and gas fields." The statement emphasized that "the Kurdish community is indigenous to the Syrian state, which ensures this community's right to citizenship and all of its constitutional rights."