The United Nations on March 3 urgently called for civilian protection amid growing violence and instability in the Middle East—and particularly in regard to the ongoing US and Israeli military operations against Iran. The UN urged a thorough investigation into a deadly strike on a girls' school in Iran, and requested the disclosure of all relevant information.

The US Treasury Department on March 2 imposed sanctions on the Rwanda Defense Force (RDF) and four of its top military officials over their support, training, and fighting alongside M23 rebels in the Democratic Republic of Congo (DRC).

Amnesty International on Feb. 27 pressed for Algerian authorities to ensure that the retrial of 94 people in the violent events of August 2021 in the Kabylie region complies with international human rights safeguards, emphasizing opposition to use of the death penalty and warning against any form of torture.

On Feb. 28, the United States and Israel launched coordinated military strikes on Iran, hitting targets in Tehran, Isfahan, Qom and other cities across 24 provinces. Iran's Red Crescent reported at least 201 people killed and 700 injured. US President Donald Trump announced "major combat operations" and openly urged regime change. Iran retaliated by launching missiles at Israel and US military installations across the Gulf States.

Violence has once again broken out between Afghanistan and Pakistan, with Islamabad declaring "open war" on Kabul. Late on Feb. 26, Afghan forces fired on military bases across the border in Pakistan, reportedly using drones. Pakistan retaliated early overnight on Feb. 27, bombing what it said were military and infrastructure targets in Kabul and several border provinces. Afghanistan's Islamic Emirate government said its attacks were a response to Pakistani airstrikes on Feb. 21 and 22 that reportedly killed at least 13 civilians in Nangarhar province. Pakistan accuses the Taliban-led government of harboring fighters from the Tehrik-e Taliban Pakistan (TTP)—accused of being behind recent attacks in Islamabad and Peshawar. Afghan Minister of Interior Sirajuddin Haqqani said the "doors for dialogue" remain open but insisted that if Afghanistan continues to be attacked, it will respond. Iran, a mutual neighbor, has offered to mediate between the two sides. Türkiye and Qatar helped to forge a fragile ceasefire after a previous flare-up in October.

The UN Office of the High Commissioner for Human Rights (OHCHR) on Feb. 20 released a report warning that the rapid expansion of cyber-fraud compounds in Southeast Asia has resulted in widespread human rights abuses. The OHCHR described the phenomenon as a "wicked problem" requiring coordinated, human rights-based responses rather than enforcement-only crackdowns.

On the fourth anniversary of Russia's full-scale invasion of Ukraine on Feb. 24, Amnesty International called on the international community to maintain a steadfast commitment to hold Russia accountable under international law for its crimes and aggression.

EU foreign ministers must use their upcoming meeting with Nikolai Mladenov, director-general of the Board of Peace (BoP) and "High Representative" for Gaza, to ensure that Palestinians' rights are among the board's highest priorities, Amnesty International urged in a statement Feb. 23.