The World Food Programme (WFP) warned March 17 that the escalating hostilities in the Middle East could lead to record levels of food insecurity, and the largest disruption in the global economy and humanitarian efforts since the COVID-19 pandemic.

United Nations officials said on March 10 that US and Israeli airstrikes on fuel depots in Tehran have released large amounts of toxic pollutants, producing acidic "black rain" across parts of the capital.

The United Nations on March 3 urgently called for civilian protection amid growing violence and instability in the Middle East—and particularly in regard to the ongoing US and Israeli military operations against Iran. The UN urged a thorough investigation into a deadly strike on a girls' school in Iran, and requested the disclosure of all relevant information.

On the fourth anniversary of Russia's full-scale invasion of Ukraine on Feb. 24, Amnesty International called on the international community to maintain a steadfast commitment to hold Russia accountable under international law for its crimes and aggression.

The Trump administration appears close to launching military strikes on Iran. The US is amassing a large strike force in the Middle East, including two aircraft carriers, over a dozen warships, and advanced fighter jets, suggesting preparations for a prolonged war. After first threatening military action in January following a protest crackdown in Iran that killed thousands, US officials now say a decision could come within days or weeks, depending on the outcome of now-stalled negotiations over Iran's uranium enrichment and missile development programs. Israeli Prime Minister Benjamin Netanyahu has said any deal must dismantle both programs. Iran's leaders may view forfeiting these means of deterrence against foreign intervention as more dangerous than a war.

Pakistan's Balochistan has just witnessed one of the province's deadliest ever episodes: a wave of attacks and clashes across several cities that left dozens of civilians, fighters, and security personnel dead, with official but unconfirmed tolls as high as 200 overall. It marked the latest escalation in decades of conflict between separatist groups and the Pakistani state in Balochistan, where the central government has long been accused of exploiting rich resources while marginalizing the local population.

Amnesty International on Feb. 3 condemned both the January attack by the US military on Venezuela and the abuses long committed by the ousted Maduro government.

The Syrian interim government and the Kurdish-led Syrian Democratic Forces (SDF) reached an agreement Jan. 18 to immediately halt fighting and integrate SDF-held areas into state institutions. The deal follows days of renewed clashes, in which government forces routed SDF strongholds in the city of Aleppo and then pushed east, taking several towns that had been under the control of the Kurdish-led autonomous administration. Just hours before the agreement was reached, autonomous authorities in the Kurdish region, known as Rojava, had announced a "general mobilization" in support of the SDF, citing an "existential war" launched by Damascus against their territory.